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[疑似卵巢良性肿瘤与生育能力]

[Presumed ovarian benign tumors and fertility].

作者信息

Aubard Y, Poirot C

机构信息

Service de gynécologie-obstétrique, hôpital Mère-Enfant, CHU de Limoges, 7, avenue Dominique-Larey, 87042 Limoges, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2013 Dec;42(8):794-801. doi: 10.1016/j.jgyn.2013.09.034. Epub 2013 Nov 7.

Abstract

We reviewed the studies about fertility-sparing in young patient presenting a benign ovarian tumor. It appears that more than the histologic nature of the ovarian cysts, it is the surgical treatment of the cyst which may decrease fertility. Some good practice of surgical procedures must be kept in mind when one manages a benign ovarian tumor in a young patient wishing to preserve her fertility: surgery should be avoided as much as possible; kystectomy is better than oophorectomy; no radical surgery should be done without pathological certitudes; electrocoagulation must be avoided on the cyst walls. In some situations, fertility is specially endangered: bilateral ovarian cysts, recurrence or strong probability of recurrence (endometriomas), poor ovarian reserve (previous chemo- or radiotherapy, age>35, premature ovarian failure). In these situations, a pre-operative assessment of the ovarian reserve could be useful. Beside the surgical 'good procedures', gamete cryopreservation procedures could be used. Cryopreservation of mature oocytes (after ovarian hyperstimulation) or in vitro mature oocytes (after antral follicle retrieval) can be proposed. Ovarian tissue cryopreservation is another option. Oocyte (or embryos) cryopreservation can be proposed before or after the surgery. The global management of benign ovarian tumors in young patients should be decided between surgeons and specialists in reproductive biology.

摘要

我们回顾了有关年轻患者良性卵巢肿瘤保留生育功能的研究。似乎相较于卵巢囊肿的组织学性质,囊肿的手术治疗可能更会降低生育能力。在处理希望保留生育功能的年轻患者的良性卵巢肿瘤时,必须牢记一些手术操作的良好做法:应尽可能避免手术;囊肿切除术优于卵巢切除术;在没有病理确诊的情况下不应进行根治性手术;必须避免对囊肿壁进行电凝。在某些情况下,生育能力会特别受到威胁:双侧卵巢囊肿、复发或复发可能性大(子宫内膜异位症)、卵巢储备功能差(既往化疗或放疗、年龄>35岁、卵巢早衰)。在这些情况下,术前评估卵巢储备功能可能会有帮助。除了手术“良好操作”外,还可采用配子冷冻保存方法。可以建议冷冻保存成熟卵母细胞(卵巢超刺激后)或体外成熟卵母细胞(窦卵泡采集后)。卵巢组织冷冻保存是另一种选择。卵母细胞(或胚胎)冷冻保存可在手术前或手术后进行。年轻患者良性卵巢肿瘤的整体管理应由外科医生和生殖生物学专家共同决定。

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