Kałużna-Czaplińska Joanna, Zurawicz Ewa, Jóźwik Jagoda
Institute of General and Ecological Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Institute of General and Ecological Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:128-35. doi: 10.1016/j.jchromb.2013.10.026. Epub 2013 Oct 22.
Chromatographic methods find application in the diagnostics and prognosis of diseases. They are used in finding new biomarkers, which may result in early medical intervention. Early diagnosis and intervention are especially important in the case of diseases of unknown etiology. One of these is autism. Autism is a neurodevelopmental disorder characterized by severe impairment in reciprocal social interaction and communication and a pattern of repetitive or stereotyped behavior. Organic acids are intermediate metabolites of all major groups of organic cellular components and can play a role in the pathogenesis of autism. This review presents information about abnormal levels of some organic acids observed in the urine of children with autism and determination of acids with the use of chromatographic techniques. 342 literature sources on frequency (2005-2012) of the use of chromatographic methods in the determination of organic compounds in various body fluids were searched.
色谱法在疾病的诊断和预后中得到应用。它们被用于寻找新的生物标志物，这可能会带来早期医疗干预。对于病因不明的疾病，早期诊断和干预尤为重要。自闭症就是其中之一。自闭症是一种神经发育障碍，其特征是在相互社交互动和沟通方面存在严重障碍，以及重复或刻板行为模式。有机酸是所有主要有机细胞成分组的中间代谢产物，可能在自闭症的发病机制中起作用。本综述介绍了自闭症儿童尿液中观察到的一些有机酸水平异常的信息，以及使用色谱技术测定这些酸的情况。检索了342篇关于2005 - 2012年色谱法用于测定各种体液中有机化合物的频率的文献来源。
