Matthews Marguerite, Nigg Joel T, Fair Damien A
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR, 97239, USA.
Curr Top Behav Neurosci. 2014;16:235-66. doi: 10.1007/7854_2013_249.
Over the last two decades, there have been numerous technical and methodological advances available to clinicians and researchers to better understand attention deficit hyperactivity disorder (ADHD) and its etiology. Despite the growing body of literature investigating the disorder's pathophysiology, ADHD remains a complex psychiatric disorder to characterize. This chapter will briefly review the literature on ADHD, with a focus on its history, the current genetic insights, neurophysiologic theories, and the use of neuroimaging to further understand the etiology. We address some of the major concerns that remain unclear about ADHD, including subtype instability, heterogeneity, and the underlying neural correlates that define the disorder. We highlight that the field of ADHD is rapidly evolving; the descriptions provided here will hopefully provide a sturdy foundation for which to build and improve our understanding of the disorder.
在过去二十年中,临床医生和研究人员可以利用众多技术和方法学进展来更好地理解注意力缺陷多动障碍(ADHD)及其病因。尽管研究该疾病病理生理学的文献不断增加,但ADHD仍然是一种难以表征的复杂精神疾病。本章将简要回顾关于ADHD的文献,重点关注其历史、当前的遗传学见解、神经生理学理论以及利用神经影像学进一步理解病因。我们探讨了一些关于ADHD仍不清楚的主要问题,包括亚型不稳定性、异质性以及定义该疾病的潜在神经关联。我们强调ADHD领域正在迅速发展;这里提供的描述有望为建立和改善我们对该疾病的理解提供坚实的基础。