Laboratory of translational immunology, University Medical Center Utrecht , Lundlaan 6, 3584 EA Utrecht, The Netherlands.
Expert Rev Clin Immunol. 2013 Dec;9(12):1193-204. doi: 10.1586/1744666X.2013.850031.
Accelerated aging of the immune system (immune aging), represented by telomere shortening, has been implicated in a variety of rheumatic diseases. Studies addressing telomere shortening in rheumatic diseases so far yielded controversial results. The current review aims to provide an overview on the role of immune aging in a plethora of immune-mediated conditions including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis. The main question this review aims to answer is whether rheumatic diseases cause accelerated aging or that accelerated aging drives rheumatic diseases.
免疫系统的加速老化（免疫衰老），表现为端粒缩短，与多种风湿性疾病有关。迄今为止，研究端粒缩短在风湿性疾病中的作用得出了有争议的结果。本综述旨在提供免疫衰老在多种免疫介导的疾病中的作用概述，包括系统性硬化症、类风湿关节炎、系统性红斑狼疮和骨关节炎。本综述旨在回答的主要问题是风湿性疾病是否导致加速老化，还是加速老化导致风湿性疾病。
