“A 型”与“B 型”原花青素间键的比例影响肠道外致病性大肠杆菌侵袭肠道上皮细胞。
Ratio of "A-type" to "B-type" proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells.
机构信息
Department of Food Science, University of Wisconsin-Madison , 1605 Linden Drive, Madison, Wisconsin 53706, United States.
出版信息
J Agric Food Chem. 2014 May 7;62(18):3919-25. doi: 10.1021/jf403839a. Epub 2013 Nov 18.
Gut colonization by extra-intestinal pathogenic Escherichia coli (ExPEC) increases the risk of subsequent infections, including urinary tract infection and septicemia. Previous work suggests that cranberry proanthocyanidins (PAC) interact with bacterial surface factors, altering bacterial interaction with host cells. Methods were developed to determine if ratios of "A-type" to "B-type" interflavan bonds in PAC affect ExPEC agglutination and invasion of enterocytes. In cranberries, 94.5% of PAC contain one or more "A-type" bonds, whereas in apples, 88.3% of PAC contain exclusively "B-type" bonds. Results show that cranberry "A-type" PAC have greater bioactivity than apple "B-type" PAC for increasing ExPEC agglutination and decreasing ExPEC epithelial cell invasion.
肠道外致病性大肠杆菌（ExPEC）定植会增加随后感染的风险，包括尿路感染和败血症。先前的研究表明，蔓越莓原花青素（PAC）与细菌表面因子相互作用，改变细菌与宿主细胞的相互作用。本研究旨在确定 PAC 中“A 型”到“B 型”间苯二酚键的比例是否会影响 ExPEC 的凝集和肠上皮细胞的侵袭。在蔓越莓中，94.5%的 PAC 含有一个或多个“A 型”键，而在苹果中，88.3%的 PAC 仅含有“B 型”键。结果表明，蔓越莓“A 型”PAC 比苹果“B 型”PAC 具有更高的活性，可增加 ExPEC 的凝集并减少 ExPEC 上皮细胞的侵袭。
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