Huttenlocher P R, Picchietti D L, Roos R P, Cashman N R, Horowitz B, Horowitz M S
Ann Neurol. 1986 Mar;19(3):303-5. doi: 10.1002/ana.410190317.
Five patients with clinically advanced subacute sclerosing panencephalitis (SSPE) were given human leukocyte interferon (IFN) by the lumbar route, 1 million IU every other day for a total of 30 days. Intrathecal IFN produced a meningeal inflammatory reaction in all patients and was associated with transient hemiparesis in 1. It persisted in the cerebrospinal fluid at measurable levels for 48 hours after a single injection. Although improvement was temporally related to intrathecal IFN in 1 patient, it is not clear whether this was induced by IFN or a spontaneous remission. A randomized controlled trial would be necessary to evaluate IFN critically as a therapy for SSPE.
5例临床诊断为晚期亚急性硬化性全脑炎（SSPE）的患者接受了经腰椎途径给予的人白细胞干扰素（IFN）治疗，隔日100万国际单位，共30天。鞘内注射IFN在所有患者中均引起了脑膜炎症反应，其中1例患者出现了短暂性偏瘫。单次注射后，脑脊液中可测量水平的IFN持续存在48小时。尽管1例患者的病情改善在时间上与鞘内注射IFN有关，但尚不清楚这是由IFN诱导还是自发缓解。有必要进行一项随机对照试验，以严格评估IFN作为SSPE治疗方法的效果。
