Grimaldi L M, Martino G V
Clinica Neurologica IV Università di Milano, IRCCS, Ospedale San Raffaele.
Ital J Neurol Sci. 1991 Apr;12(2):187-91. doi: 10.1007/BF02337032.
Oligoclonal bands are a constant, non-modifiable feature of CSF examination in SSPE. We studied CSF oligoclonal IgG banding pattern in a long-surviving SSPE patient treated with serial courses of intrathecal alpha-IFN. alpha-IFN administration did not significantly modify the clinical status of the patient. Oligoclonal IgG banding pattern varied during the 58 month-long treatment. Oligoclonal bands disappeared at the end of the first course only to reappear during the third course, 2 years later, with a different electrophoretic pattern. We conclude that oligoclonal bands may transiently disappear from the CSF of long-surviving SSPE patients. Although alpha-IFN treatment induces no clinical improvement, it might affect the quality of Ig production.
寡克隆带是亚急性硬化性全脑炎（SSPE）脑脊液检查中持续存在、不可改变的特征。我们研究了一名长期存活的接受鞘内注射α-干扰素系列疗程治疗的SSPE患者的脑脊液寡克隆IgG带型。给予α-干扰素并未显著改变该患者的临床状态。在长达58个月的治疗期间，寡克隆IgG带型发生了变化。寡克隆带仅在第一个疗程结束时消失，却在2年后的第三个疗程中再次出现，且电泳图谱不同。我们得出结论，寡克隆带可能会在长期存活的SSPE患者的脑脊液中短暂消失。尽管α-干扰素治疗未带来临床改善，但它可能会影响Ig产生的质量。
