Kanje M, Ekström P, Deinum J, Wallin M
Biochim Biophys Acta. 1986 Apr 25;856(3):437-42. doi: 10.1016/0005-2736(86)90134-3.
Gossypol at micromolar concentrations (2 microM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 microM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.
已发现微摩尔浓度（2微摩尔）的棉酚可抑制青蛙坐骨神经中的轴突运输和微粒体ATP酶活性，尽管轴突微管以及AMP、ADP和ATP的神经元含量未受影响。在略高浓度（30 - 40微摩尔）时，棉酚还会抑制微管组装和神经元能量代谢。棉酚在神经中蓄积，结果表明棉酚可能是一种强效神经毒素。
