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穿透性阳离子的流出速率并不取决于线粒体的能量状态。

[The rate of outflow of penetrating cations does not depend on the energy state of mitochondria].

作者信息

Skul'skiĭ I A, Glazunov V V, Savina M V

出版信息

Biofizika. 1986 Mar-Apr;31(2):343-5.

PMID:2421784
Abstract

Inhibiton of respiration at 0 degrees C believed to decrease the membrane potential in mitochondria did not lead to a substantial acceleration of the efflux of penetrating cations (triphenylmethylphosphonium, Cs- valinomycin). On the contrary the energy-dependent influx of the cations was rapidly inhibited indicating that there was no prolonged delay in the membrane deenergization. Low sensitivity of the cation efflux to respiration inhibition suggests under the conditions studied the metabolic component of the membrane potential to be rather small.

摘要

0℃下对呼吸的抑制被认为会降低线粒体膜电位,但这并未导致穿透性阳离子(三苯甲基鏻、铯-缬氨霉素)外流的显著加速。相反,阳离子的能量依赖性内流被迅速抑制,这表明膜去极化没有长时间延迟。在所研究的条件下,阳离子外流对呼吸抑制的低敏感性表明膜电位的代谢成分相当小。

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