真菌类天然产物中瓜氨酰丁氨酸起始单元的共同起源。
A common origin for guanidinobutanoate starter units in antifungal natural products.
机构信息
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (UK).
出版信息
Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13096-9. doi: 10.1002/anie.201308136. Epub 2013 Nov 11.
PMID:24218293
Abstract
Keeping it basic: Arginine provides the exotic 4-guanidinobutanoate starter unit for two different types of zwitterionic polyketide (an example for one type is shown in the picture) produced by the same Streptomyces bacterium. The three-step precursor pathway is initiated by a remarkable decarboxylating monooxygenase with high specificity for arginine.
摘要
保持基本
精氨酸提供了奇异的 4-胍基丁酸起始单元，用于由同一种链霉菌产生的两种不同类型的两性离子聚酮（一种类型的示例如图所示）。三步前体途径由一种对精氨酸具有高特异性的显著脱羧单加氧酶启动。
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