Saland L C, Wallace J A, Comunas F
Brain Res. 1986 Mar 19;368(2):310-8. doi: 10.1016/0006-8993(86)90575-5.
Serotonin-immunoreactive (5-HT-IR) nerve fibers observed in the pars intermedia and pars nervosa of the rat pituitary gland were examined after treatment of animals with antiserotonergic or anti-catecholaminergic drugs. p-Chlorophenylalanine, (PCPA), an inhibitor of 5-HT synthesis, eliminated staining in both areas of pituitary gland. p-Chloroamphetamine (PCA), a serotonin neurotoxin, did not produce a significant change in 5-HT-IR from control tissue. Unexpectedly, 6-hydroxydopamine (6-OHDA), a catecholamine neurotoxin, eliminated 5-HT staining in the pars intermedia, but not in the pars nervosa. These observations suggest that 5-HT present in fibers innervating the intermediate and neural lobes is synthesized in axons locally, or is taken up into fibers from extrinsic sources. In addition, catecholamines and 5-HT may co-exist in nerve terminals of both lobes of the pituitary gland.
在用抗血清素能或抗儿茶酚胺能药物处理动物后，对大鼠垂体中间部和神经部中观察到的5-羟色胺免疫反应性（5-HT-IR）神经纤维进行了检查。对氯苯丙氨酸（PCPA），一种5-羟色胺合成抑制剂，消除了垂体两个区域的染色。对氯苯丙胺（PCA），一种血清素神经毒素，与对照组织相比，5-HT-IR没有产生显著变化。出乎意料的是，儿茶酚胺神经毒素6-羟基多巴胺（6-OHDA）消除了中间部的5-羟色胺染色，但神经部没有。这些观察结果表明，支配中间叶和神经叶的纤维中存在的5-羟色胺是在轴突中局部合成的，或者是从外部来源摄取到纤维中的。此外，儿茶酚胺和5-羟色胺可能共存于垂体两个叶的神经末梢中。
