Hayakawa Y, Ishizaki H, Tanabe S, Kimura A, Yamamichi N
Dermatologica. 1986;172(3):169-72. doi: 10.1159/000249324.
Squamous cell carcinoma with hypercalcemia and leukocytosis arising from burn scars in a 45-year-old man is reported. Hypercalcemia and leukocytosis improved with pepleomycin treatment and worsened with recurrence of the tumor. Serum levels of parathyroid hormone, prostaglandin E and 25-OH-Vitamin D were within normal limits. Autopsy did not disclose any bone metastases or abnormalities of the parathyroid glands. It is suggested that hypercalcemia and leukocytosis were due to factors produced by the squamous cell carcinoma. This is the fifth reported case of cutaneous squamous cell carcinoma associated with hypercalcemia in the absence of bone metastasis or parathyroid gland abnormalities.
报告了一名45岁男性因烧伤瘢痕发生伴有高钙血症和白细胞增多症的鳞状细胞癌。博来霉素治疗后高钙血症和白细胞增多症改善，肿瘤复发时病情恶化。甲状旁腺激素、前列腺素E和25-羟基维生素D的血清水平在正常范围内。尸检未发现任何骨转移或甲状旁腺异常。提示高钙血症和白细胞增多症是由鳞状细胞癌产生的因素所致。这是第五例报道的无骨转移或甲状旁腺异常的与高钙血症相关的皮肤鳞状细胞癌病例。
