Tanaka N, Okabe T, Tanaka N, Take Y, Inouye Y, Nakamura S, Nakashima H, Yamamoto N
Jpn J Cancer Res. 1986 Apr;77(4):324-6.
In the course of screening for inhibitors of reverse transcriptase, we have isolated an inhibitor from a strain of Nocardia and identified it as sakyomicin A. The antibiotic blocks avian myeloblastosis virus reverse transcriptase reaction: IC50 was ca. 30 micrograms/ml by the method employed. The drug affects proliferation of HTLV-III/LAV in HTLV-I-carrying MT-4 cells: ca. 60% inhibition was observed at an antibiotic concentration of 1.0 microgram/ml and ca. 20% inhibition at 0.1 microgram/ml, and there was no significant cytotoxicity.
在筛选逆转录酶抑制剂的过程中，我们从诺卡氏菌属的一个菌株中分离出一种抑制剂，并将其鉴定为酒霉素A。该抗生素可阻断禽成髓细胞瘤病毒逆转录酶反应：采用的方法测得IC50约为30微克/毫升。该药物影响携带HTLV-I的MT-4细胞中HTLV-III/LAV的增殖：在抗生素浓度为1.0微克/毫升时观察到约60%的抑制率，在0.1微克/毫升时约为20%的抑制率，且无明显细胞毒性。
