Department of Biomedical Sciences, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431-0991, USA.
Immunol Res. 2013 Dec;57(1-3):81-5. doi: 10.1007/s12026-013-8460-5.
Semaphorins are a family of proteins that were originally described for their role in axonal guidance. Studies now show that semaphorins encompass many physiological functions outside of the nervous system, including immune responses. Semaphorin7A (SEMA7A) belongs to the "immune" semaphorin group and has been shown to play a crucial role in regulating immune responses. In this review, we discuss the structure and function of SEMA7A as well as its role in innate and adaptive immunity [corrected].We further describe SEMA7A's involvement in inflammatory disease and its emergent role in cancer.
信号蛋白是一类蛋白家族，最初因其在轴突导向中的作用而被描述。现在的研究表明，信号蛋白在神经系统之外具有许多生理功能，包括免疫反应。信号蛋白 7A（SEMA7A）属于“免疫”信号蛋白组，已被证明在调节免疫反应中起着至关重要的作用。在这篇综述中，我们讨论了 SEMA7A 的结构和功能及其在先天和适应性免疫中的作用[已更正]。我们进一步描述了 SEMA7A 参与炎症性疾病及其在癌症中的新兴作用。
