Naeser Vibeke, Kahr Niklas, Stensballe Lone Graff, Kyvik Kirsten Ohm, Skytthe Axel, Backer Vibeke, Carson Charlotte Giwercman, Thomsen Simon Francis
Department of Respiratory Medicine, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
J Allergy (Cairo). 2013;2013:712090. doi: 10.1155/2013/712090. Epub 2013 Oct 9.
Aim. To study the impact of birth characteristics on the risk of atopic dermatitis in a twin population. Methods. In a population-based questionnaire study of 10,809 twins, 3-9 years of age, from the Danish Twin Registry, we identified 907 twin pairs discordant for parent-reported atopic dermatitis. We cross-linked with data from the Danish National Birth Registry and performed cotwin control analysis in order to test the impact of birth characteristics on the risk of atopic dermatitis. Results. Apgar score, OR (per unit) = 1.23 (1.06-1.44), P = 0.008, and female sex, OR = 1.31 (1.06-1.61), P = 0.012, were risk factors for atopic dermatitis in cotwin control analysis, whereas birth anthropometric factors were not significantly related to disease development. Risk estimates in monozygotic and dizygotic twins were not significantly different for the identified risk factors. Conclusions. In this population-based cotwin control study, high Apgar score was a risk factor for atopic dermatitis. This novel finding must be confirmed in subsequent studies.
目的。研究出生特征对双胎人群中特应性皮炎风险的影响。方法。在一项基于问卷调查的研究中，我们从丹麦双胞胎登记处选取了10,809对3至9岁的双胞胎，确定了907对父母报告有特应性皮炎的不一致双胞胎对。我们将数据与丹麦国家出生登记处的数据进行交叉关联，并进行同卵双胞胎对照分析，以测试出生特征对特应性皮炎风险的影响。结果。在同卵双胞胎对照分析中，阿氏评分，比值比（每单位）= 1.23（1.06 - 1.44），P = 0.008，以及女性性别，比值比 = 1.31（1.06 - 1.61），P = 0.012，是特应性皮炎的风险因素，而出生人体测量因素与疾病发展无显著相关性。对于已确定的风险因素，单卵双胞胎和双卵双胞胎的风险估计无显著差异。结论。在这项基于人群的同卵双胞胎对照研究中，高阿氏评分是特应性皮炎的一个风险因素。这一新颖发现必须在后续研究中得到证实。
