Thomsen Simon Francis, van der Sluis Sophie, Kyvik Kirsten Ohm, Backer Vibeke
Department of Dermato-Allergology Gentofte Hospital 2900 Hellerup, Denmark.
J Allergy (Cairo). 2012;2012:125367. doi: 10.1155/2012/125367. Epub 2012 Nov 20.
Aim. To identify risk factors for urticaria, to determine the relative proportion of the susceptibility to urticaria that is due to genetic factors in an adult clinical twin sample, and to further determine whether the genetic susceptibility to urticaria overlaps with the genetic susceptibility to atopic diseases. Methods. A total of 256 complete twin pairs and 63 single twins, who were selected from sibships with self-reported asthma via a questionnaire survey of 21,162 adult twins from the Danish Twin Registry, were clinically interviewed about a history of urticaria and examined for atopic diseases. Data were analysed with Cox proportional hazards regression and variance components models. Results. A total of 151 individuals (26%) had a history of urticaria, whereas 24 (4%) had had symptoms within the past year. Female sex, HR = 2.09 (1.46-2.99), P = 0.000; hay fever, HR = 1.92 (1.36-2.72), P = 0.000; and atopic dermatitis, HR = 1.44 (1.02-2.06), P = 0.041 were significant risk factors for urticaria. After adjustment for sex and age at onset of urticaria in the index twin, the risk of urticaria was increased in MZ cotwins relative to DZ cotwins, HR = 1.42 (0.63-3.18), P = 0.394. Genetic factors explained 45% (16-74%), P = 0.005, of the variation in susceptibility to urticaria. The genetic correlation between urticaria and hay fever was 0.45 (0.01-0.89), P = 0.040. Conclusions. Susceptibility to urticaria is partly determined by genetic factors. Urticaria is more common in women, and in subjects with hay fever and atopic dermatitis, and shares genetic variance with hay fever.
目的。识别荨麻疹的风险因素，确定成年临床双胞胎样本中由遗传因素导致的荨麻疹易感性的相对比例，并进一步确定荨麻疹的遗传易感性是否与特应性疾病的遗传易感性重叠。方法。通过对丹麦双胞胎登记处的21162名成年双胞胎进行问卷调查，从自述患有哮喘的同胞兄弟姐妹中选取了256对完整双胞胎和63名单胞胎，对其进行荨麻疹病史的临床访谈并检查是否患有特应性疾病。采用Cox比例风险回归和方差成分模型对数据进行分析。结果。共有151人（26%）有荨麻疹病史，而24人（4%）在过去一年中有症状。女性，HR = 2.09（1.46 - 2.99），P = 0.000；花粉症，HR = 1.92（1.36 - 2.72），P = 0.000；以及特应性皮炎，HR = 1.44（1.02 - 2.06），P = 0.041是荨麻疹的显著风险因素。在对索引双胞胎荨麻疹发病时的性别和年龄进行调整后，同卵双胞胎患荨麻疹的风险相对于异卵双胞胎有所增加，HR = 1.42（0.63 - 3.18），P = 0.394。遗传因素解释了荨麻疹易感性变异的45%（16 - 74%），P = 0.005。荨麻疹与花粉症之间的遗传相关性为0.45（0.01 - 0.89），P = 0.040。结论。荨麻疹易感性部分由遗传因素决定。荨麻疹在女性、患有花粉症和特应性皮炎的人群中更为常见，并且与花粉症存在遗传方差重叠。
