Larsen F S, Holm N V, Henningsen K
J Am Acad Dermatol. 1986 Sep;15(3):487-94.
Atopic dermatitis is a multifactorial disease that seems both to rise in frequency and to be dependent on a genetic predisposition. In order to clarify these issues we encircled a representative twin series with atopic dermatitis from a total twin population of 592 like-sexed twin pairs. We found that the cumulative incidence rate (0-7 years) of atopic dermatitis in Denmark has increased significantly from 0.03 for the birth cohort 1960-1964 to 0.10 for the birth cohort 1970-1974, that monozygotic twin pairs are more often concordant for atopic dermatitis than dizygotic twin pairs, that monozygotic twins run a risk of 0.86 of having atopic dermatitis if the twin partner has the disease, whereas the disease risk of 0.21 run by dizygotic partners does not differ from the frequency seen in ordinary brothers and sisters. The results indicate that genetic factors play a decisive role in the development of atopic dermatitis and that widespread environmental factors are operating in genetically susceptible individuals.
特应性皮炎是一种多因素疾病，其发病率似乎在上升，且依赖于遗传易感性。为了阐明这些问题，我们从592对同性双胞胎的总群体中圈定了一个有代表性的特应性皮炎双胞胎系列。我们发现，丹麦特应性皮炎的累积发病率（0至7岁）已从1960 - 1964年出生队列的0.03显著增加到1970 - 1974年出生队列的0.10；同卵双胞胎比异卵双胞胎更常患特应性皮炎；如果双胞胎一方患有特应性皮炎，同卵双胞胎患该病的风险为0.86，而异卵双胞胎的患病风险为0.21，这与普通兄弟姐妹的发病率无差异。结果表明，遗传因素在特应性皮炎的发病中起决定性作用，广泛的环境因素在遗传易感个体中起作用。
