Jabalameli Mitra, Hazegh Pooya, Talakoub Reihanak
Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2013 Jul 30;2:68. doi: 10.4103/2277-9175.115816. eCollection 2013.
Recently, the preemptive analgesic effects of subcutaneous infiltration of tramadol (T) in the site of incision have not been extensively studied. In this study, we investigated the effect of subcutaneous T infiltration before the incision of surgery on post-operative pain, in lower abdomen surgeries.
This double-blind study was carried out on 90 patients (18-65 years) of American Society Anesthesiologists physical status I and II who were candidates for a lower abdomen surgery during 2011. They were randomly assigned to receive preemptive subcutaneous T or normal saline (NS). The visual analogue scale for pain (VAS) in rest and cough position and opium total dose consumption were compared between two groups in times 0, 15, 30, 60 min and 2, 4, 6, 12, 24 h after the surgery.
The VAS in cough and rest position in the first 24 h following the surgery was lower in group T (P < 0.05). Opium consumption was lower in group T (P < 0.05).
Subcutaneous preemptive infiltration of T before surgical incision reduces post-operative opioid consumption.
近期，曲马多（T）在切口部位皮下浸润的超前镇痛效果尚未得到广泛研究。在本研究中，我们调查了手术切口前皮下注射T对下腹部手术术后疼痛的影响。
本双盲研究对2011年期间90例美国麻醉医师协会身体状况I级和II级、拟行下腹部手术的患者（18 - 65岁）进行。他们被随机分配接受超前皮下注射T或生理盐水（NS）。比较两组患者在术后0、15、30、60分钟以及2、4、6、12、24小时静息和咳嗽时的视觉模拟疼痛评分（VAS）以及阿片类药物总消耗量。
术后前24小时，T组患者咳嗽和静息时的VAS较低（P < 0.05）。T组阿片类药物消耗量较低（P < 0.05）。
手术切口前皮下预先浸润T可减少术后阿片类药物的消耗量。
