Sarwar M S, Adnan T, Hossain M D, Uddin S M N, Hossain M S, Al Baker S M E, Uddin M N, Islam M S
Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh.
Department of Cardiology, Laksham Upazilla Health Complex, Comilla, Bangladesh.
Drug Res (Stuttg). 2014 Jul;64(7):353-7. doi: 10.1055/s-0033-1358704. Epub 2013 Nov 13.
Serum lipid levels are greatly controlled by genetic and environmental factors. When investigating the relationship between lipid disturbances and hypertension it is necessary to use local data on blood lipid profile in each region. Unfortunately, there is no literature reporting the lipid profile in hypertensive patients in coastal region of Bangladesh. The present study was conducted as a case-control study with 100 hypertensive patients as cases and equal number of normotensive individuals as controls. Socio-demographic, anthropometric and clinical data of both patients and controls were collected. Serum lipid parameters were analyzed biochemically. Independent sample t-test, Chi-Square test and Pearson's correlation test were done for the statistical analysis using the statistical software package SPSS. Our study found that serum total cholesterol (TC), triglyceride (TG), LDL, VLDL, TC/HDL, LDL/HDL were significantly higher (p<0.05) whereas the level of HDL cholesterol was significantly lower in hypertensive patients as compared to control subjects (p<0.05). Pearson's correlation analysis reveals that HDL cholesterol was inversely correlated with systolic and diastolic blood pressure in both patient and control groups. But serum TC, TG, LDL and HDL cholesterol were directly correlated with systolic and diastolic blood pressure in both groups. This study explored that hypertensive patients have higher level of TC, TG, LDL and VLDL cholesterol but lower level of HDL cholesterol than the normotensive subjects. Routine investigation of lipid profile in hypertensive patients may help to prevent further aggravation and risks of coronary artery diseases.
血清脂质水平受遗传和环境因素的极大控制。在研究脂质紊乱与高血压之间的关系时，有必要使用每个地区关于血脂谱的本地数据。不幸的是，没有文献报道孟加拉国沿海地区高血压患者的血脂谱情况。本研究作为一项病例对照研究进行，以100名高血压患者为病例，数量相等的血压正常个体作为对照。收集了患者和对照的社会人口统计学、人体测量学和临床数据。对血清脂质参数进行生化分析。使用统计软件包SPSS进行独立样本t检验、卡方检验和皮尔逊相关检验以进行统计分析。我们的研究发现，与对照组相比，高血压患者的血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、TC/高密度脂蛋白（HDL）、LDL/HDL显著更高（p<0.05），而HDL胆固醇水平显著更低（p<0.05）。皮尔逊相关分析表明，在患者组和对照组中，HDL胆固醇与收缩压和舒张压呈负相关。但两组中血清TC、TG、LDL和HDL胆固醇与收缩压和舒张压呈正相关。本研究探索发现，高血压患者的TC、TG、LDL和VLDL胆固醇水平高于血压正常者，但HDL胆固醇水平低于血压正常者。对高血压患者进行血脂谱的常规检查可能有助于预防冠状动脉疾病的进一步加重和风险。
