谷氨酸作为抗癌剂：概述。
Glutamic acid as anticancer agent: An overview.
机构信息
Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh, India.
出版信息
Saudi Pharm J. 2013 Oct;21(4):337-43. doi: 10.1016/j.jsps.2012.12.007.
Abstract
The objective of the article is to highlight various roles of glutamic acid like endogenic anticancer agent, conjugates to anticancer agents, and derivatives of glutamic acid as possible anticancer agents. Besides these emphases are given especially for two endogenous derivatives of glutamic acid such as glutamine and glutamate. Glutamine is a derivative of glutamic acid and is formed in the body from glutamic acid and ammonia in an energy requiring reaction catalyzed by glutamine synthase. It also possesses anticancer activity. So the transportation and metabolism of glutamine are also discussed for better understanding the role of glutamic acid. Glutamates are the carboxylate anions and salts of glutamic acid. Here the roles of various enzymes required for the metabolism of glutamates are also discussed.
摘要
本文的目的是强调谷氨酸的各种作用，如内源性抗癌剂、与抗癌剂的结合物以及谷氨酸的衍生物作为潜在的抗癌剂。除此之外，特别强调了谷氨酸的两种内源性衍生物，即谷氨酰胺和谷氨酸。谷氨酰胺是谷氨酸的衍生物，由谷氨酸和氨在谷氨酰胺合成酶催化的耗能反应中形成。它也具有抗癌活性。因此，也讨论了谷氨酰胺的运输和代谢，以更好地理解谷氨酸的作用。谷氨酸盐是谷氨酸的羧酸根阴离子和盐。这里还讨论了代谢谷氨酸盐所需的各种酶的作用。
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