Bard R H, Mydlo J H, Freed S Z
Urology. 1986 May;27(5):447-50. doi: 10.1016/0090-4295(86)90412-7.
Implantation of human renal adenocarcinoma in the rabbit cornea has resulted in new vascular growth from the limbus toward the tumor implant. This suggests that renal adenocarcinoma elaborates tumor angiogenesis factor (TAF) which stimulates endothelial cell growth. Such a substance could conceivably be responsible for the luxuriant vascularity of most renal adenocarcinomas. Conversely, absence or diminished secretion of TAF may be responsible for the hypovascular papillary renal adenocarcinomas and their recognized relatively benign clinical behavior.
将人类肾腺癌植入兔角膜后，已导致从角膜缘向肿瘤植入物方向出现新的血管生长。这表明肾腺癌能产生刺激内皮细胞生长的肿瘤血管生成因子（TAF）。可以想象，这样一种物质可能是大多数肾腺癌丰富血管形成的原因。相反，TAF的缺乏或分泌减少可能是乳头状低血管性肾腺癌及其公认的相对良性临床行为的原因。
