Frederick J L, Shimanuki T, diZerega G S
Science. 1984 Apr 27;224(4647):389-90. doi: 10.1126/science.6200930.
Angiogenesis was observed and measured after injection of human follicular fluid into rabbit corneas. Undiluted human follicular fluid stimulated angiogenesis in every case, with new blood vessels visible 3 days after injection and extending 2.0 millimeters from the corneal scleral limbus into the injection site by day 15. Stimulation of angiogenesis was lost by heating or diluting the follicular fluid but was retained after charcoal stripping or dialysis. Human follicular fluid contains an angiogenic factor that may be associated with perifollicular neovascularization during folliculogenesis.
将人卵泡液注射到兔角膜后，观察并测量了血管生成情况。未稀释的人卵泡液在每种情况下均能刺激血管生成，注射后3天可见新血管，到第15天时新血管从角膜巩膜缘延伸2.0毫米进入注射部位。加热或稀释卵泡液会导致血管生成刺激作用丧失，但经活性炭吸附或透析后仍保留该作用。人卵泡液含有一种血管生成因子，可能与卵泡发生过程中卵泡周围的新生血管形成有关。
