Liu Zhen, Wang Jie, Lin Hong-Sheng, Li Yong
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(15):2458-62.
To observe the effection of immune reconstitution efficiency and the immune function on Immune 2 with HAART to HIV/AIDS patients which poor immune reconstitution after HAART.
Two hundred and sixty four patients failure to immune reconstitution after HAART were randomly divided into treatment group (131 cases) and control group (133 cases), respectively, using Immune 2 plus HAART and placebo combined with HAART for 6 months. the CD4, CD8, CD45RA, CD45RO, CD4CD28, CD8CD28, CD8CD38, HLA-DR and CD4CD25 were observed in order to evaluate the immune reconstitution efficiency.
After the intervention for 6 months, the effective rate of treatment group (34.48%) was significantly superior to the control group (21.37%) (P = 0.0217). Treated group could significantly increased the CD4, CD45RA, CD45RO cell counts compared with control group (P < 0.05); CD8, CD3, CD4CD28 absolute count comparison between the two groups had no significant difference; CD8CD28 relative counting the treatment group group significantly increased (P < 0.05) compared to the control; CD4CD28, CD8CD38, CD8DR, CD4CD25 relative counting groups showed no significant difference.
Immune 2 can effectively improve the immune reconstitution efficiency, CD4 counts, CD45RA counts and CD45RO counts of patients after HAART, therefore promoting immune reconstitution.
观察免疫调节剂2（Immune 2）对高效抗逆转录病毒治疗（HAART）后免疫重建不佳的HIV/AIDS患者免疫重建效率及免疫功能的影响。
将264例HAART后免疫重建失败的患者随机分为治疗组（131例）和对照组（133例），分别采用免疫调节剂2联合HAART及安慰剂联合HAART治疗6个月。观察CD4、CD8、CD45RA、CD45RO、CD4CD28、CD8CD28、CD8CD38、HLA - DR和CD4CD25，以评估免疫重建效率。
干预6个月后，治疗组有效率（34.48%）显著优于对照组（21.37%）（P = 0.0217）。治疗组CD4、CD45RA、CD45RO细胞计数较对照组显著增加（P < 0.05）；两组间CD8、CD3、CD4CD28绝对计数比较无显著差异；治疗组CD8CD28相对计数较对照组显著增加（P < 0.05）；CD4CD28、CD8CD38、CD8DR、CD4CD25相对计数组间无显著差异。
免疫调节剂2可有效提高HAART后患者的免疫重建效率、CD4计数、CD45RA计数和CD45RO计数，从而促进免疫重建。
