Zhang Nannan, Wang Mengyuan, Gao Ling, Zhang Congying, Tang Xiaoguang, Liu Xianjun, Bai Chunying
Key Laboratory of Research on Human Genetic Diseases at Universities of Inner Mongolia Autonomous Region, School of Basic Medicine, Chifeng University, Chifeng, China.
College of Biology and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Front Med (Lausanne). 2024 Aug 8;11:1322870. doi: 10.3389/fmed.2024.1322870. eCollection 2024.
With the global spread of human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), the pursuit of potent treatments has ascended as a paramount concern in global healthcare. Traditional Chinese medicine (TCM) has been used for thousands of years in China and other East Asian countries and it offers remedies for an extensive array of ailments, including HIV and AIDS. This review focuses on the clinical significance of single herbs and composite tonics in TCM with antiviral activity against HIV. Initially, the anti-HIV activity of single herbs was analyzed in detail. Many herbs have been shown to have significant anti-HIV activity. The active ingredients of these herbs exhibit their anti-HIV effects through various mechanisms, such as inhibiting viral replication, preventing viral binding to host cells, and interfering with the viral lifecycle. Furthermore, we delved into the clinical significance of HIV-associated formulations provided as a result of Chinese compound prescription. These combinations of herbal ingredients are designed to amplify therapeutic efficacy and minimize adverse effects. Clinical trials have demonstrated the therapeutic benefits of these prescriptions for individuals infected with HIV. The intricate composition of these prescriptions potentially augments their anti-HIV activity through synergistic effects. Additionally, this review underscores the clinical importance of TCM in the context of HIV treatment. While numerous herbs and prescriptions exhibit anti-HIV activity, their safety and efficacy in clinical applications warrant further investigation. When combined with contemporary antiretroviral drugs, TCM may serve as an adjunctive therapy, assisting in reducing side effects, and enhancing patients' quality of life. To optimally harness these natural resources, further exploration is imperative to ascertain their efficacy, safety, and optimal utilization, thereby offering a broader spectrum of therapeutic options for HIV-afflicted individuals.
随着人类免疫缺陷病毒（HIV）感染和获得性免疫缺陷综合征（AIDS）在全球范围内的传播，寻求有效的治疗方法已成为全球医疗保健领域的首要关注点。中药在中国和其他东亚国家已经使用了数千年，它为包括HIV和AIDS在内的一系列疾病提供治疗方法。本综述重点关注具有抗HIV病毒活性的单味中药和复方滋补剂在中医中的临床意义。首先，详细分析了单味中药的抗HIV活性。许多中药已被证明具有显著的抗HIV活性。这些中药的活性成分通过多种机制发挥抗HIV作用，如抑制病毒复制、阻止病毒与宿主细胞结合以及干扰病毒生命周期。此外，我们深入探讨了中医复方制剂在HIV治疗方面的临床意义。这些草药成分的组合旨在增强治疗效果并最小化不良反应。临床试验已经证明了这些方剂对HIV感染者的治疗益处。这些方剂复杂的成分可能通过协同作用增强其抗HIV活性。此外，本综述强调了中医在HIV治疗中的临床重要性。虽然许多草药和方剂具有抗HIV活性，但其在临床应用中的安全性和有效性仍有待进一步研究。当与现代抗逆转录病毒药物联合使用时，中药可以作为辅助治疗，有助于减少副作用并提高患者的生活质量。为了最佳地利用这些自然资源，必须进一步探索以确定其疗效、安全性和最佳使用方法，从而为受HIV影响的个体提供更广泛的治疗选择。
