Department of Neurology, Centre Hospitalier de Luxembourg (CHL), 4 rue Barblé, L-1210, Luxembourg, Luxemburg.
Nutr J. 2013 Nov 15;12(1):147. doi: 10.1186/1475-2891-12-147.
Physical exercise and a Mediterranean diet improve serum lipid profile. The present work studied whether red wine has an effect on top of a lipid-lowering lifestyle in patients with carotid atherosclerosis.
A prospective randomised unblinded trial was performed from 2009 to 2011 in 108 patients with carotid atherosclerosis, 65% of whom were already on statin therapy with a low mean LDL of 104.9 mg/dl. Half of them were advised to follow a modified Mediterranean diet and to perform moderate physical exercise during 30 min/day (lifestyle changes) for 20 weeks. Within these two groups half of the patients were randomised either to avoid any alcohol or to drink 100 ml of red wine (women) or 200 ml of red wine (men) daily.
LDL was significantly lowered by 7% in the lifestyle-changes group compared to the no-lifestyle-changes group (p = 0.0296) after 20 weeks. Lifestyle changes lowered the LDL/HDL ratio after 20 weeks by 8% (p = 0.0242) and red wine independently by 13% (p = 0.0049). The effect on LDL/HDL ratio after 20 weeks was, however, more pronounced in the non-LC group. Total cholesterol (-6%; p = 0.0238) and triglycerides (-13%; p = 0.0361) were lowered significantly by lifestyle changes after 20 weeks compared to the no-lifestyle-changes group. Lipoprotein (a) was not significantly affected by any intervention. The given results are per ITT analysis.
Lifestyle changes including a modified Mediterranean diet and physical exercise as well as a glass of red wine daily improve independently the LDL/HDL ratio in patients with carotid arteriosclerosis even though the vast majority of them was already on statin therapy.
体育锻炼和地中海饮食可改善血清脂质谱。本研究旨在探讨红酒对颈动脉粥样硬化患者降脂生活方式的影响。
2009 年至 2011 年进行了一项前瞻性随机非盲试验，共纳入 108 例颈动脉粥样硬化患者，其中 65%已接受他汀类药物治疗，平均 LDL 为 104.9mg/dl。其中一半患者被建议采用改良地中海饮食，并在 20 周内每天进行 30 分钟的适度体育锻炼（生活方式改变）。在这两组中，每组有一半患者被随机分为不饮酒组或每天饮用 100ml 红酒（女性）或 200ml 红酒（男性）。
与无生活方式改变组相比，生活方式改变组 20 周后 LDL 降低 7%（p=0.0296）。生活方式改变 20 周后 LDL/HDL 比值降低 8%（p=0.0242），红酒单独降低 13%（p=0.0049）。然而，20 周后非 LC 组 LDL/HDL 比值的降低更为明显。与无生活方式改变组相比，生活方式改变 20 周后总胆固醇（-6%；p=0.0238）和甘油三酯（-13%；p=0.0361）明显降低。任何干预措施均未显著影响脂蛋白（a）。这些结果是根据 ITT 分析得出的。
包括改良地中海饮食和体育锻炼在内的生活方式改变以及每天一杯红酒可独立改善颈动脉粥样硬化患者的 LDL/HDL 比值，尽管其中绝大多数患者已接受他汀类药物治疗。
