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饮酒与血脂状况的影响：一项临床试验的系统评价与荟萃分析

The effects of wine consumption and lipid profile: A systematic review and meta-analysis of clinical trials.

作者信息

Lucerón-Lucas-Torres Maribel, Ruiz-Grao Marta C, Cavero-Redondo Iván, di Lorenzo Chiara, Pascual-Morena Carlos, Priego-Jiménez Susana, Gómez-Guijarro Dolores, Álvarez-Bueno Celia

机构信息

Centro de Estudios Socio-Sanitarios, Grupo de investigación Age-ABC Universidad de Castilla-La Mancha; Nursing Faculty, University of Castilla-La Mancha, Albacete, Spain.

Centro de Estudios Socio-Sanitarios, Grupo de investigación Age-ABC Universidad de Castilla-La Mancha; Nursing Faculty, University of Castilla-La Mancha, Albacete, Spain.

出版信息

J Nutr Health Aging. 2025 Jun;29(6):100539. doi: 10.1016/j.jnha.2025.100539. Epub 2025 Mar 23.

DOI:10.1016/j.jnha.2025.100539
PMID:40121963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12172967/
Abstract

BACKGROUND AND OBJECTIVE

The aim of this study was to analyze the effects of wine consumption on the lipid profile, distinguishing between triglycerides, total cholesterol, LDL, HDL and fibrinogen.

METHODS

We examined the MEDLINE (via PubMed), Scopus, Cochrane, and Web of Science databases to conduct this systematic review and meta-analysis. PROSPERO has already recorded this study under registration number CRD42023396666.

RESULTS

Thirty-three studies were included in this systematic review, and 29 were included in the meta-analysis. The pooled ES for the effect of red wine consumption on the different lipid profile parameters was significant only for the effect of red wine on the LDL parameter in the prepost studies (-0.29 (95% CI -0.54, -0.05)). The pooled ES for the effect of white wine in prepost studies and clinical trials for the effect of wine consumption on the different parameters did not show any significant results.

CONCLUSION

This systematic review and meta-analysis revealed that wine consumption has an effect on reducing LDL and has no effect on total cholesterol, HDL, triglycerides, or fibrinogen. This research revealed that the duration of the intervention affects triglyceride and total cholesterol levels, indicating that longer interventions are more effective for these two parameters.

REGISTRATION ID

CRD42023396666 (PROSPERO). URL REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=396666.

摘要

背景与目的

本研究旨在分析饮酒对血脂谱的影响，区分甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白和纤维蛋白原。

方法

我们检索了MEDLINE（通过PubMed）、Scopus、Cochrane和科学网数据库来进行这项系统评价和荟萃分析。PROSPERO已将本研究登记在注册号CRD42023396666下。

结果

本系统评价纳入了33项研究，荟萃分析纳入了29项研究。在前后对照研究中，饮用红酒对不同血脂谱参数影响的合并效应量仅在红酒对低密度脂蛋白参数的影响方面具有统计学意义（-0.29（95%CI -0.54，-0.05））。在前后对照研究和临床试验中，饮用白葡萄酒对不同参数影响的合并效应量未显示出任何显著结果。

结论

本系统评价和荟萃分析表明，饮酒对降低低密度脂蛋白有作用，而对总胆固醇、高密度脂蛋白、甘油三酯或纤维蛋白原无作用。本研究表明，干预持续时间会影响甘油三酯和总胆固醇水平, 这表明较长时间的干预对这两个参数更有效。

注册号

CRD42023396666（PROSPERO）。注册网址：https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=396666 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/39623e23c329/gr3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/1a7b030e53fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/4fdcb19c7da9/gr2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/39623e23c329/gr3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/1a7b030e53fa/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/4fdcb19c7da9/gr2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f149/12172967/39623e23c329/gr3a.jpg

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A High-Quality Diet, as Measured by the DASH Score, Is Associated with a Lower Risk of Metabolic Syndrome and Visceral Obesity.通过DASH评分衡量的高质量饮食与代谢综合征和内脏肥胖风险较低相关。
Biomedicines. 2023 Jan 23;11(2):317. doi: 10.3390/biomedicines11020317.
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Beneficial Effects of Red Wine Polyphenols on Human Health: Comprehensive Review.
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Curr Issues Mol Biol. 2023 Jan 17;45(2):782-798. doi: 10.3390/cimb45020052.
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Longitudinal Association between Physical Activity, Blood Lipids, and Risk of Dyslipidemia among Chinese Adults: Findings from the China Health and Nutrition Surveys in 2009 and 2015.中国成年人身体活动与血脂水平及血脂异常风险的纵向关联：来自 2009 年和 2015 年中国健康与营养调查的数据。
Nutrients. 2023 Jan 10;15(2):341. doi: 10.3390/nu15020341.
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World Heart Federation Cholesterol Roadmap 2022.世界心脏联合会胆固醇路线图 2022 年版
Glob Heart. 2022 Oct 14;17(1):75. doi: 10.5334/gh.1154. eCollection 2022.
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Addiction. 2022 Dec;117(12):3024-3036. doi: 10.1111/add.16003.
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