荷兰年轻成年女性中1型侵袭性肺炎球菌疾病发病率上升。
Increased incidence of serotype-1 invasive pneumococcal disease in young female adults in The Netherlands.
作者信息
Van Mens S P, Van Deursen A M M, Meijvis S C A, Vlaminckx B J M, Sanders E A M, De Melker H E, Schouls L M, Van Der Ende A, De Greeff S C, Rijkers G T
机构信息
St Antonius Hospital,Nieuwegein,The Netherlands.
University Medical Centre,Utrecht,The Netherlands.
出版信息
Epidemiol Infect. 2014 Sep;142(9):1996-9. doi: 10.1017/S0950268813002860. Epub 2013 Nov 11.
Abstract
Analysis of the Dutch national invasive pneumococcal disease (IPD) surveillance data by sex reveals an increase in the incidence of serotype-1 disease in young female adults in The Netherlands after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the national immunization schedule. This has led to an overall increase in IPD in women aged 20-45 years, which was not observed in men of the same age. No other differences in serotype shifts possibly induced by the introduction of PCV7 were observed between the sexes in this age group. Serotype 1 is a naturally fluctuating serotype in Europe and it has been associated with disease in young healthy adults before. It remains uncertain whether or not there is an association between the observed increase in serotype-1 disease in young female adults and the implementation of PCV7 in The Netherlands.
摘要
按性别对荷兰全国侵袭性肺炎球菌疾病（IPD）监测数据进行分析后发现，在国家免疫规划中引入7价肺炎球菌结合疫苗（PCV7）后，荷兰年轻成年女性中1型疾病的发病率有所上升。这导致20至45岁女性的IPD总体增加，而同龄男性中未观察到这种情况。在该年龄组的两性之间，未观察到因引入PCV7可能导致的血清型转变的其他差异。1型在欧洲是一种自然波动的血清型，之前曾与年轻健康成年人的疾病有关。在荷兰，年轻成年女性中观察到的1型疾病增加与PCV7的实施之间是否存在关联仍不确定。
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