Schubert B, Hering S, Bodewei R, Wollenberger A
Biull Eksp Biol Med. 1986 May;101(5):581-3.
A patch-clamp method was used to study the effects of the phenotiazine antiarrhythmic drug ethmozine (E) on the fast sodium inward current (INa) in freshly isolated heart muscle cells of adult rats. At a concentration of 10(-5) M E caused INa inhibition that could be enhanced by increasing the frequency of depolarization. This inhibition was reversible. After the termination of repetitive depolarization the amplitude of INa recovered with a time constant of about 10 sec. These findings may help to explain the therapeutic efficiency of E in high frequency cardiac rhythm disturbances.
采用膜片钳技术研究吩噻嗪类抗心律失常药物乙吗噻嗪（E）对成年大鼠新鲜分离心肌细胞快钠内向电流（INa）的影响。浓度为10^(-5) M时，E可引起INa抑制，且这种抑制作用可通过增加去极化频率而增强。该抑制作用是可逆的。重复去极化终止后，INa的幅度以约10秒的时间常数恢复。这些发现可能有助于解释E对高频心律失常的治疗效果。
