[Effect of ethmozine and its diethylamino analog on the slow incurrent and excurrent ion flows of cardiac atrial fibers].

The effects of ethmozine (2 X 10(-5) g/ml) and diethylamine derivative of ethmozine (DAD of ethmozine) (2 X 10(-5) g/ml) on slow inward and outward currents were investigated by means of the voltage clamp method in frog auricular trabeculae. Ethmozine increased the maximal value of the slow inward current by 62 +/- 11% (n = 5) while DAD of ethmozine decreased it by 54 +/- 17% (n = 3). The control value of the slow inward current was restored after 30 min of wash out. Ethmozine and DAD of ethmozine had no significant effect on steady-state outward current.