Schubert B, Bodewei R, Hering S, Wollenberger A
Eur J Pharmacol. 1986 Jul 31;126(3):309-12. doi: 10.1016/0014-2999(86)90063-4.
The effect of ethacyzine (a diethylamine analogue of ethmozine) on the rapid inward sodium current (INa) was studied in single rat ventricular muscle cells by a patch clamp technique. Extracellular application of 3 microM ethacyzine depressed the INa in a use-dependent fashion. Rest recovery from the use-dependent block by ethacyzine followed an exponential time course with a time constant of about 215 +/- 40 s (n = 4, mean +/- S.E.).
采用膜片钳技术在单个大鼠心室肌细胞中研究了乙卡嗪（乙吗噻嗪的二乙胺类似物）对快速内向钠电流（INa）的影响。细胞外给予3 microM乙卡嗪以使用依赖的方式抑制INa。乙卡嗪所致使用依赖阻滞的恢复遵循指数时间进程，时间常数约为215±40秒（n = 4，平均值±标准误）。
