Malakhova N V, Raushenbakh M O
Biull Eksp Biol Med. 1986 May;101(5):605-7.
Transplacental administration of serotonin metabolite 5-methoxyindole-3-acetic acid possessing blastomogenic activity induced the development of malignant and benign neoplasms (lymphosarcomas, adenomas, hepatomas and other tumours) in 84% of C57BL/6 mouse progeny. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were more malignant.
经胎盘给予具有致瘤活性的血清素代谢物5-甲氧基吲哚-3-乙酸,可使84%的C57BL/6小鼠后代发生恶性和良性肿瘤(淋巴肉瘤、腺瘤、肝癌及其他肿瘤)。肿瘤数量显著高于对照组,出现时间更早且恶性程度更高。