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[血清素衍生物5-甲氧基吲哚乙酸的经胎盘致癌作用]

[Transplacental carcinogenic effect of the serotonin derivative 5-methoxyindoleacetic acid].

作者信息

Malakhova N V, Raushenbakh M O

出版信息

Biull Eksp Biol Med. 1986 May;101(5):605-7.

PMID:2423155
Abstract

Transplacental administration of serotonin metabolite 5-methoxyindole-3-acetic acid possessing blastomogenic activity induced the development of malignant and benign neoplasms (lymphosarcomas, adenomas, hepatomas and other tumours) in 84% of C57BL/6 mouse progeny. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were more malignant.

摘要

经胎盘给予具有致瘤活性的血清素代谢物5-甲氧基吲哚-3-乙酸,可使84%的C57BL/6小鼠后代发生恶性和良性肿瘤(淋巴肉瘤、腺瘤、肝癌及其他肿瘤)。肿瘤数量显著高于对照组,出现时间更早且恶性程度更高。

相似文献

1
[Transplacental carcinogenic effect of the serotonin derivative 5-methoxyindoleacetic acid].[血清素衍生物5-甲氧基吲哚乙酸的经胎盘致癌作用]
Biull Eksp Biol Med. 1986 May;101(5):605-7.
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[Transplacental blastomogenic effect of p-hydroxyphenyl lactic acid].对羟基苯乳酸的经胎盘致瘤作用
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Eksp Onkol. 1985;7(4):26-9.
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Blastomogenic activity of p-hydroxyphenyllactic acid in mice.对羟基苯乳酸在小鼠体内的致瘤活性。
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7,12-Dimethylbenz[a]anthracene-induced perinatal carcinogenesis and its modulation by butylated hydroxyanisole in mice.7,12-二甲基苯并[a]蒽诱导的小鼠围产期致癌作用及其受丁基羟基茴香醚的调节
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[Liver tumors induced in mice by prenatal and postnatal administration of ortho-aminoazotoluene].
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