Rauschenbach M O, Zharova E I, Sergeeva T I, Ivanova V D, Probatova N A
Cancer Res. 1975 Mar;35(3):577-85.
Blastomogenic activity of p-hydroxyphenyllactic acid was established by prolonged s.c. administration into C57BL/6 and CC57BR mice. Phenyllactic acid was also tested and was not blastomogenic under the same conditions. The preparations in aqueous solutions were injected into the dorsal region twice weekly in 1.5-mg doses. The total dose per mouse was 42 mg p-hydroxyphenyllactic acid or 50 mg phenyllactic acid. The resorptive character and many forms of blastomogenic activity of p-hydroxphenyllactic acid were shown. It induced neoplasms of varied histogenesis (leukemias, adenomas, hepatomas, and tumors of the vascular tissue),including benign and malignant tumors and precancerous conditions of the urniary bladder.
对羟基苯乳酸的致瘤活性是通过长期皮下注射到C57BL/6和CC57BR小鼠体内确定的。在相同条件下也测试了苯乳酸，其没有致瘤性。将水溶液制剂以1.5毫克的剂量每周两次注射到背部区域。每只小鼠的总剂量为42毫克对羟基苯乳酸或50毫克苯乳酸。显示了对羟基苯乳酸的吸收特性和多种形式的致瘤活性。它诱发了不同组织发生类型的肿瘤（白血病、腺瘤、肝癌和血管组织肿瘤），包括良性和恶性肿瘤以及膀胱的癌前病变。
