Zharova E I, Sergeeva T I, Makhalova N V, Romanenko V I, Chitiridi N G
Biull Eksp Biol Med. 1979 Jan;87(1):39-41.
Transplacental administration of tyrosine metabolite p-hydroxyphenyl lactic acid having blastomogenic activity induced development of malignant and benign neoplasms (leukemias and lymphosarcomas, adenomas and pulmonary carcinoma, hepatomas, papillomas, and cancer of the urinary bladder and other tumours) in progeny of CC57BR and C57BL mouse strains, in 88 and 78% of cases, respectively. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were of more malignant character. The role of endogenous blastomogenic substances in the development of leukemias in the newborn and yound children is discussed.
具有致瘤活性的酪氨酸代谢产物对羟基苯乳酸经胎盘给药，分别在CC57BR和C57BL小鼠品系的后代中诱发了恶性和良性肿瘤（白血病和淋巴肉瘤、腺瘤和肺癌、肝癌、乳头状瘤以及膀胱癌和其他肿瘤），发生率分别为88%和78%。肿瘤数量显著高于对照组，出现得更早，且恶性程度更高。文中讨论了内源性致瘤物质在新生儿和幼儿白血病发生中的作用。
