胆固醇生物合成过程中C-4去甲基化的机制。
The mechanism of C-4 demethylation during cholesterol biosynthesis.
作者信息
Wilton D C, Akhtar M
出版信息
Biochem J. 1975 Jul;149(1):233-5. doi: 10.1042/bj1490233.
Abstract
The conversion of 4,4-dimethylcholest-7-enol into 4alpha-methylcholest-7-enol by rat liver microsomal preparations involves the decarboxylation of a sterol 3-oxo-4alpha-carboxylic acid. By using an (18)O-labelled substrate it was shown that this decarboxylation does not involve a Schiff-base intermediate.
摘要
大鼠肝脏微粒体制剂将4,4-二甲基胆甾-7-烯醇转化为4α-甲基胆甾-7-烯醇的过程涉及甾醇3-氧代-4α-羧酸的脱羧反应。通过使用（18）O标记的底物表明，这种脱羧反应不涉及席夫碱中间体。
相似文献
1
The mechanism of C-4 demethylation during cholesterol biosynthesis.胆固醇生物合成过程中C-4去甲基化的机制。
Biochem J. 1975 Jul;149(1):233-5. doi: 10.1042/bj1490233.
2
The metabolic sequence by which some 4,4-dimethyl sterols are converted into cholesterol.一些4,4-二甲基甾醇转化为胆固醇的代谢序列。
Biochem J. 1974 Oct;144(1):59-68. doi: 10.1042/bj1440059.
3
4
Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.微粒体甾醇4-羧酸脱羧酶的部分纯化
J Biol Chem. 1972 Jan 10;247(1):9-15.
5
Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.胆固醇生物合成中C-4去甲基化的机制与调控研究。3':5'-环磷酸腺苷的作用。
Biochem J. 1971 Nov;125(2):625-34. doi: 10.1042/bj1250625.
6
7
8
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.两种莫里斯肝癌中微粒体甲基甾醇脱甲基酶的特性研究
Cancer Res. 1976 Feb;36(2 Pt 1):291-7.
9
10
Studies on an unusual N-dealkylation reaction. II. Characteristics of the enzyme system and a proposed pathway for the reaction.关于一种异常的N-脱烷基化反应的研究。II. 酶系统的特性及该反应的一种推测途径。
J Pharmacol Exp Ther. 1973 Mar;184(3):729-38.
引用本文的文献
1
The chemical mechanism of sheep liver 6-phosphogluconate dehydrogenase. A Schiff-base intermediate is not involved.绵羊肝脏6-磷酸葡萄糖酸脱氢酶的化学机制。不涉及席夫碱中间体。
Biochem J. 1986 Mar 15;234(3):671-7. doi: 10.1042/bj2340671.
本文引用的文献
1
Ketonic intermediates in the demethylation of lanosterol.羊毛甾醇去甲基化过程中的酮类中间体。
J Biol Chem. 1963 May;238:1661-4.
2
Oxaloacetate decarboxylase from cod. Mechanism of action and stereoselective reduction of pyruvate by borohydride.鳕鱼中的草酰乙酸脱羧酶。硼氢化物对丙酮酸的作用机制及立体选择性还原
Biochemistry. 1968 Dec;7(12):4303-9. doi: 10.1021/bi00852a023.
3
Oxaloacetate decarboxylases of rat liver.大鼠肝脏中的草酰乙酸脱羧酶
Biochem J. 1973 Dec;135(4):667-72. doi: 10.1042/bj1350667.
4
18O studies of the mechanisms of yeast and muscle aldolases.酵母和肌肉醛缩酶作用机制的氧-18研究
Biochemistry. 1974 Oct 8;13(21):4371-5. doi: 10.1021/bi00718a020.
5
Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.微粒体甾醇4-羧酸脱羧酶的部分纯化
J Biol Chem. 1972 Jan 10;247(1):9-15.
6
The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.胆固醇生物合成过程中14,15-双键的形成与还原
Biochem J. 1971 Jan;121(1):131-7. doi: 10.1042/bj1210131.
7
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.氧化甾醇脱甲基化的组成反应研究。3-酮甾体中间体的形成与代谢。
J Biol Chem. 1968 Nov 10;243(21):5546-55.
8
The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.7-脱氢胆固醇的生物转化及关于双键还原的评论
Biochem J. 1968 Feb;106(4):803-10. doi: 10.1042/bj1060803.
Zotero 插件