Myelin-associated glycoprotein in the developing human retina.

The immunohistochemical presence of myelin-associated glycoprotein (MAG) in Müller cells of the developing human retina was examined with rat monoclonal antibodies to MAG and the peroxidase antiperoxidase (PAP) method of Sternberger. Retinas of various developmental stages ranging between 9-31 gestational weeks were stained. There was no staining in the retinas of 9-12-week embryos. Between 13-16 gestational weeks the staining was faint and located mostly in the inner and middle portion of the retina, primarily around the optic nerve head. After midterm, Müller cells invariably stained through all retinal layers. The staining increased gradually up to the twenty-third gestational week, when it reached the level found in the retinas of newborn children.