Stefansson K, Molnar M L, Marton L S, Molnar G K, Mihovilovic M, Tripathi R C, Richman D P
Nature. 1984;307(5951):548-50. doi: 10.1038/307548a0.
The human retina is unmyelinated, but structural similarities have been noted between Müller cells, the main glial cell type of retina, and oligodendrocytes, the myelin-forming cells of the central nervous system. We now show that antibodies against myelin-associated glycoprotein, a minor component of central and peripheral myelin so far found only in myelin and myelin-forming cells, also stain Müller cells. Immunoblot analysis of retinal proteins indicates that the antigen detected is myelin associated glycoprotein. These results suggest a closer relationship between Müller cells and oligodendrocytes than previously suspected and raise questions about the functional role of myelin-associated glycoprotein.
人类视网膜是无髓鞘的，但视网膜主要的神经胶质细胞类型即米勒细胞与中枢神经系统中形成髓鞘的少突胶质细胞之间已被注意到存在结构相似性。我们现在表明，针对髓鞘相关糖蛋白的抗体也能使米勒细胞着色，髓鞘相关糖蛋白是中枢和外周髓鞘的一种次要成分，迄今为止仅在髓鞘和形成髓鞘的细胞中发现。对视网膜蛋白的免疫印迹分析表明检测到的抗原是髓鞘相关糖蛋白。这些结果表明米勒细胞与少突胶质细胞之间的关系比以前所怀疑的更为密切，并引发了关于髓鞘相关糖蛋白功能作用的问题。
