Lucarelli M J, Pepose J S, Arnold A C, Foos R Y
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO.
Ophthalmology. 1991 Nov;98(11):1652-6. doi: 10.1016/s0161-6420(91)32080-3.
To further characterize the nature of retinal periphlebitis and retinitis in multiple sclerosis, immunoperoxidase studies were performed on retinal tissue from multiple sclerosis patients at autopsy. Antibodies against myelin basic protein stained the optic nerve but not the retina. Both normal and multiple sclerosis retinas showed staining of Müller cells with Leu-7 (a monoclonal antibody that cross-reacts with myelin associated glycoprotein and natural killer cells). Nerve fiber bundles of the optic nerve in cases with multiple sclerosis and controls also showed staining with Leu-7 antibody. Tissue-bound IgG was demonstrated on retinal ganglion cells in six of seven multiple sclerosis cases but not in controls.
为了进一步明确多发性硬化症中视网膜静脉周围炎和视网膜炎的性质，对多发性硬化症患者尸检时获取的视网膜组织进行了免疫过氧化物酶研究。抗髓鞘碱性蛋白抗体可使视神经染色，但不能使视网膜染色。正常视网膜和多发性硬化症视网膜均显示用Leu-7（一种与髓鞘相关糖蛋白和自然杀伤细胞发生交叉反应的单克隆抗体）对Müller细胞进行染色。多发性硬化症病例和对照组的视神经神经纤维束也显示用Leu-7抗体染色。在7例多发性硬化症病例中的6例视网膜神经节细胞上检测到组织结合IgG，而对照组未检测到。
