Analytical Chemistry Division, Oak Ridge National Laboratory, 3763-6365, Oak Ridge, TN.
J Am Soc Mass Spectrom. 1992 Sep;3(6):599-614. doi: 10.1016/1044-0305(92)85001-Z.
Collisional activation has played an essential role in the development of mass spectrometry/mass spectrometry (MS/MS). It was the first activation method to be employed and continues to be by far the most widely used. As instrumentation for MS/MS has evolved it has been found that collisional activation can be effected under a remarkably wide range of conditions for a wide range of ions. It is fair to conclude from the growth of MS/MS over the past fifteen years that collisional activation has been spectacularly successful. However, it has limitations. As a community, we have learned much over the years regarding these limitations both from empirical and fundamental points of view. This overview provides background on the development of collisional activation and discusses the importance of the interaction potential and timing on mechanisms for energy transfer. Parts of the discussion is devoted to changing reference frames from the laboratory to the center of mass to simplify visualizing what is possible and what is probable in collisional activation.
碰撞激活在质谱/质谱（MS/MS）的发展中发挥了重要作用。它是最早采用的激活方法，迄今为止仍然是应用最广泛的方法。随着 MS/MS 仪器的发展，人们发现碰撞激活可以在广泛的离子范围内，在非常广泛的条件下进行。从过去十五年 MS/MS 的发展来看，可以公平地得出结论，碰撞激活已经取得了巨大的成功。然而，它也有局限性。多年来，我们从经验和基础的角度了解了很多关于这些局限性的知识。本篇综述提供了碰撞激活发展的背景，并讨论了相互作用势能和能量转移机制的时间对其的重要性。讨论的部分内容致力于将参考框架从实验室转换到质心，以简化对碰撞激活中可能和可能的情况的可视化。
