Tanaka D, Isaacson L G, Trosko B K
J Comp Neurol. 1986 May 1;247(1):56-68. doi: 10.1002/cne.902470104.
Thalamostriatal projections from the ventral anterior nucleus (VA) were mapped by using autoradiographic and horseradish peroxidase techniques in the dog. Injections of tritiated leucine and proline into the lateral, central, and medial parts of VA resulted in anterograde label over the dorsolateral, midlateral, and dorsal parts of the head of the caudate nucleus, respectively. The dorsolateral and midlateral parts of the caudate contained the heaviest label. No silver grains were located over the medial or ventral parts of the caudate. Light to moderate label was located over the most dorsal part of the putamen. After injections of lectin-conjugated horseradish peroxidase (WGA-HRP) into the dorsolateral or intermediate areas of the head of the caudate, retrogradely labeled cells were present in the lateral and central parts of VA, respectively. In cases with dorsolateral caudate injections, labeled cells formed a narrow dorsoventrally oriented band located in the lateral part of VA whereas in the case with a larger injection into midcaudate, large numbers of labeled neurons were scattered throughout the central area of VA. Retrogradely labeled cells were also found in the rostral part of the ventral lateral nucleus (VL). Injections of WGA-HRP into the medial part of the caudate resulted in only a few labeled cells located in the dorsomedial part of VA. Combining these data with those from other studies mapping neostriatal afferents from the cerebral cortex in the dog, it is apparent that the midlateral part of the caudate receiving input from VA also receives afferents from cortical area 6. Furthermore, the dorsolateral part of the caudate that receives input from the lateral part of VA also receives afferents from cortical area 4. These results indicate that the dorsal and lateral parts of the canine caudate nucleus may constitute important links in the transmission and integration of information related to complex motor activities.
利用放射自显影和辣根过氧化物酶技术，在犬身上绘制了来自腹前核（VA）的丘脑纹状体投射图。向VA的外侧、中央和内侧部分注射氚标记的亮氨酸和脯氨酸，分别在尾状核头部的背外侧、中外侧和背侧部分产生顺行标记。尾状核的背外侧和中外侧部分标记最重。尾状核的内侧或腹侧部分没有银颗粒。壳核最背侧部分有轻度至中度标记。向尾状核头部的背外侧或中间区域注射凝集素结合辣根过氧化物酶（WGA-HRP）后，分别在VA的外侧和中央部分出现逆行标记细胞。在尾状核背外侧注射的情况下，标记细胞形成一条位于VA外侧部分的狭窄的背腹向带，而在尾状核中部较大注射的情况下，大量标记神经元散布在VA的中央区域。在腹外侧核（VL）的 Rostral 部分也发现了逆行标记细胞。向尾状核内侧部分注射WGA-HRP仅在VA的背内侧部分产生少数标记细胞。将这些数据与其他绘制犬大脑皮质新纹状体传入纤维的研究数据相结合，很明显，接受VA输入的尾状核中外侧部分也接受来自皮质6区的传入纤维。此外，接受VA外侧部分输入的尾状核背外侧部分也接受来自皮质4区的传入纤维。这些结果表明，犬尾状核的背侧和外侧部分可能是与复杂运动活动相关信息传递和整合的重要环节。
