Evans Kevin D, Volz Kevin R, Roll Shawn C, Hutmire Cristina M, Pargeon Rachel L, Buford John A, Sommerich Carolyn M
School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.
Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA.
J Diagn Med Sonogr. 2013 Sep;29(5). doi: 10.1177/8756479313503211.
This preclinical study was conducted to develop discrete sonographic instrumentation settings and also safe contrast dosing that would consistently demonstrate perineural vascularity along the median nerve. This set of imaging studies was conducted with a convenience cohort of young adult female monkeys (). Sonographic equipment settings and dosing were refined throughout the imaging series to ensure consistent contrast-enhanced ultrasound imaging. A mechanical index of 0.13 was consistently used for imaging. Perineural vessels were imaged with a suspension solution of 0.04 mL Definity/0.96 mL saline introduced over 5 minutes for a total dose of 0.8 mL of contrast solution. Blinded studies of high and low dose contrast, along with saline injections, were correctly identified by two experienced sonographers. This preclinical study established adequate equipment settings and dosing that allowed for a valid demonstration of vascularity surrounding the median nerve.
进行这项临床前研究的目的是开发离散的超声仪器设置以及安全的造影剂给药方案，以便始终如一地显示正中神经周围的神经周血管。这组影像学研究是在一组方便选取的年轻成年雌性猴子（）中进行的。在整个成像系列过程中，对超声设备设置和给药方案进行了优化，以确保获得一致的超声造影成像。成像时始终使用0.13的机械指数。通过在5分钟内注入0.04 mL Definity/0.96 mL生理盐水的悬浮液来成像神经周血管，造影剂溶液的总剂量为0.8 mL。两名经验丰富的超声检查人员能够正确识别高剂量和低剂量造影剂以及生理盐水注射的盲法研究。这项临床前研究确定了足够的设备设置和给药方案，能够有效显示正中神经周围的血管情况。
