Carbone Claudia, Cupri Sarha, Leonardi Antonio, Puglisi Giovanni, Pignatello Rosario
Section of Pharmaceutical Technology, Department of Drug Sciences, University of Catania, viale A. Doria 6, I-95125, Catania, Italy.
Pharm Pat Anal. 2013 Sep;2(5):665-77. doi: 10.4155/ppa.13.43.
Among the colloidal vectors proposed for the controlled delivery and targeting of drugs and other biologically active compounds, lipid-based nanocarriers are acquiring an increasing role due to a number of peculiar technological and physical features. Solid lipid nanoparticles, lipid nanocapsules, nanostructured lipid carriers, and drug-lipid conjugates are all examples of how it can be possible to combine the properties of the more acknowledged liposomal systems, such as biocompatibility and biodegradability, with the stability and compositional flexibility, distinctive of polymeric nanosystems. This article introduces recent patents, filed in years 2007-2013, that deal with novel or amended methods of production of the various types of lipid-based nanocarriers. Although a significant gap still remains between basic research and patenting activity in this field, many of the proposed methods can attain an industrial value. Furthermore, the critical analysis of these patents further supports the position that a general revision of patenting systems at an international level would be necessary for nanosized pharmaceutical systems.
在为药物及其他生物活性化合物的控释和靶向而提出的胶体载体中，基于脂质的纳米载体由于其诸多独特的技术和物理特性而发挥着越来越重要的作用。固体脂质纳米粒、脂质纳米囊、纳米结构脂质载体和药物 - 脂质缀合物，都是将更知名的脂质体系统的特性（如生物相容性和生物可降解性）与聚合物纳米系统特有的稳定性和组成灵活性相结合的实例。本文介绍了2007年至2013年期间提交的近期专利，这些专利涉及各类基于脂质的纳米载体的新型或改进生产方法。尽管该领域的基础研究与专利活动之间仍存在显著差距，但许多提出的方法能够获得工业价值。此外，对这些专利的批判性分析进一步支持了这样一种观点，即对于纳米级药物系统而言，有必要在国际层面全面修订专利制度。
