Carbone Claudia, Leonardi Antonio, Cupri Sarha, Puglisi Giovanni, Pignatello Rosario
Section of Pharmaceutical Technology, Department of Drug Sciences, University of Catania, Catania, Italy.
Pharm Pat Anal. 2014 Mar;3(2):199-215. doi: 10.4155/ppa.13.79.
Increasing attention is being given to lipid nanocarriers (LNs) as drug delivery systems, due to the advantages offered of a higher biocompatibility and lower toxicity compared with polymeric nanoparticles. Many administration routes are being investigated for LNs, including topical, oral and parenteral ones. LNs are also proposed for specific applications such as cancer treatment, gene therapy, diagnosis and medical devices production. However, the high number of published research articles does not match an equal amount of patents. A recent Review of ours, published in Pharmaceutical Patent Analyst, reported the patents proposing novel methods for the production of LNs. This review work discusses recent patents, filed in 2007-2013 and dealing with the industrial applications of lipid-based nanocarriers for the vectorization of therapeutically relevant molecules, as well as biotech products such as proteins, gene material and vaccines, in the pharmaceutical, diagnostic and biomedical areas.
作为药物递送系统，脂质纳米载体（LNs）正受到越来越多的关注，因为与聚合物纳米颗粒相比，它具有更高的生物相容性和更低的毒性。目前正在研究LNs的多种给药途径，包括局部、口服和肠胃外给药途径。LNs还被提议用于特定应用，如癌症治疗、基因治疗、诊断和医疗设备生产。然而，已发表的研究文章数量众多，但与之对应的专利数量却并不相同。我们最近发表在《药物专利分析》上的一篇综述报道了提出新型LNs生产方法的专利。本综述工作讨论了2007年至2013年提交的近期专利，这些专利涉及基于脂质的纳米载体在制药、诊断和生物医学领域用于治疗相关分子以及蛋白质、基因材料和疫苗等生物技术产品载体化的工业应用。
