Toll样受体4基因多态性与急性冠状动脉综合征：墨西哥人群中无关联
Toll-like receptor 4 gene polymorphisms and acute coronary syndrome: no association in a Mexican population.
作者信息
Martínez-Ríos Marco A, Vargas-Alarcón Gilberto, Vallejo Maite, Cruz-Martínez Erick, Pérez-Méndez Oscar, Medina-Andrade Ángel, De la Torre-García Mónica, Peña-Duque Marco A, Fragoso José Manuel
机构信息
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Department of Molecular Biology and Interventional Genetic Study Group in Cardiovascular Disease's, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
出版信息
Arch Cardiol Mex. 2013 Oct-Dec;83(4):257-62. doi: 10.1016/j.acmx.2013.09.001. Epub 2013 Nov 13.
OBJECTIVE
The objective of this study was to establish the role of the TLR-4 gene polymorphisms in individuals in risk of developing ACS.
METHODS
The study included 457 Mexican patients with ACS and 283 control individuals. The TLR-4 Asp299Gly and TLR-4 Thr399Ile single nucleotide polymorphisms were genotyped using 5' exonuclease TaqMan genotyping assays on an 7900HT Fast real-time PCR system according to manufacturer's instructions (Applied Biosystems, Foster City, USA).
RESULTS
The results obtained in this study showed that the frequency of the two polymorphisms (TLR-4 Asp299Gly and TLR-4 Thr399Ile) studied were similar between patients with ACS and healthy controls. Multiple logistic regression analysis showed that the largest risk factor for ACS development was given by smoking (11.88-fold increased risk), hypertension (4.32-fold increased risk), type II diabetes (3.44-fold increased risk), gender (2.32-fold increased risk), and dyslipidemia (1.52-fold increased risk).
CONCLUSION
The Asp299Gly and Thr399Ile polymorphisms were not associated with susceptibility to ACS in the Mexican population.
目的
本研究的目的是确定Toll样受体4（TLR-4）基因多态性在急性冠状动脉综合征（ACS）发病风险个体中的作用。
方法
该研究纳入了457名患有ACS的墨西哥患者和283名对照个体。根据制造商的说明（美国应用生物系统公司，福斯特城），在7900HT快速实时PCR系统上使用5'核酸外切酶TaqMan基因分型测定法对TLR-4 Asp299Gly和TLR-4 Thr399Ile单核苷酸多态性进行基因分型。
结果
本研究获得的结果表明，ACS患者和健康对照者中研究的两种多态性（TLR-4 Asp299Gly和TLR-4 Thr399Ile）的频率相似。多因素逻辑回归分析表明，ACS发生的最大危险因素是吸烟（风险增加11.88倍）、高血压（风险增加4.32倍）、2型糖尿病（风险增加3.44倍）、性别（风险增加2.32倍）和血脂异常（风险增加1.52倍）。
结论
在墨西哥人群中，Asp299Gly和Thr399Ile多态性与ACS易感性无关。
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