Kütük Nükhet, Baş Burcu, Soylu Emrah, Gönen Zeynep Burçin, Yilmaz Canay, Balcioğlu Esra, Özdamar Saim, Alkan Alper
Assistant Professor, Department of Oral and Maxillofacial Surgery, Erciyes University Faculty of Dentistry, Melikgazi, Kayseri, Turkey.
Associate Professor, Department of Oral and Maxillofacial Surgery, Ondokuz Mayis University Faculty of Dentistry, Samsun, Turkey.
J Oral Maxillofac Surg. 2014 Feb;72(2):277-84. doi: 10.1016/j.joms.2013.09.011. Epub 2013 Nov 13.
The purpose of the present study was to explore the potential use of platelet-rich-plasma (PRP) in the treatment of temporomandibular joint osteoarthritis (TMJ-OA).
Surgical defects were created bilaterally on the condylar fibrocartilage, hyaline cartilage, and bone to induce an osteoarthritic TMJ in rabbits. PRP was applied to the right joints of the rabbits (PRP group), and the left joints received physiologic saline (control group). After 4 weeks, the rabbits were sacrificed for histologic and scanning electron microscopy (SEM) examinations. The data were analyzed statistically.
The new bone regeneration was significantly greater in the PRP group (P < .011). Although the regeneration of the fibrocartilage and hyaline cartilage was greater in the PRP group, no statistically significant difference was found between the 2 groups. SEM showed better ultrastructural architecture of the collagen fibrils in the PRP group.
PRP might enhance the regeneration of bone in TMJ-OA.
本研究旨在探讨富血小板血浆（PRP）在颞下颌关节骨关节炎（TMJ - OA）治疗中的潜在应用。
在兔双侧髁突的纤维软骨、透明软骨和骨上制造手术缺损，以诱导兔颞下颌关节骨关节炎。将PRP应用于兔的右侧关节（PRP组），左侧关节注射生理盐水（对照组）。4周后，处死兔子进行组织学和扫描电子显微镜（SEM）检查。对数据进行统计学分析。
PRP组新骨再生明显更多（P <.011）。虽然PRP组纤维软骨和透明软骨的再生更多，但两组之间未发现统计学上的显著差异。SEM显示PRP组胶原纤维的超微结构更好。
PRP可能促进TMJ - OA中骨的再生。
