在患有新型实验性变应性脑脊髓炎的豚鼠中，体内脱髓鞘的严重程度与血清髓鞘形成抑制活性相关。
Severity of demyelination in vivo correlates with serum myelination inhibition activity in guinea pigs having a new form of experimental allergic encephalomyelitis.
作者信息
Bourdette D N, Driscoll B F, Seil F J, Kies M W, Alvord E C
出版信息
Neurochem Pathol. 1986 Feb;4(1):1-9. doi: 10.1007/BF02834294.
PMID:2423931
Abstract
Guinea pigs received a suboptimal transfer of lymphocytes sensitized to myelin basic protein (BP) and were then immunized with guinea pig BP, BP plus chicken brain or chicken myelin, or chicken brain alone. Sera from these animals were tested for the presence of myelinotoxic antibodies, as detected by the myelination inhibition assay. Myelination inhibition activity correlated with the histologic severity of demyelination.
摘要
豚鼠接受了对髓鞘碱性蛋白（BP）致敏淋巴细胞的次优转移，然后用豚鼠BP、BP加鸡脑或鸡髓鞘、或单独鸡脑进行免疫。通过髓鞘形成抑制试验检测这些动物血清中髓鞘毒性抗体的存在。髓鞘形成抑制活性与脱髓鞘的组织学严重程度相关。
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