Dillner Joakim
BioBanking & Molecular Resource Infrastructure of Sweden (BBMRI.se), Karolinska Institutet, S-17177 Stockholm, Sweden.
Eur J Cancer. 2015 Jun;51(9):1018-27. doi: 10.1016/j.ejca.2013.10.007. Epub 2013 Nov 13.
Population-based cancer research is paramount for controlling cancer. Cancer research is increasingly dependent on access to biospecimens from subjects that have been followed-up for future health outcomes. This is achieved using longitudinal follow-up of cohorts and biobanks using cancer registry linkages. All over the world, more and more large population-based cohorts and advanced biobanking facilities are established. International standardisation and networking in the linkage of cohorts and biobanks to cancer registries is required in order to enable international cancer research and comparability of research results. An international operating procedure and standard minimum dataset for linkages of biobanks, cohorts and cancer registries is proposed. An internationally comparable provision of well characterised study bases for molecular cancer research will be an essential prerequisite for the success of translational medicine.
基于人群的癌症研究对于控制癌症至关重要。癌症研究越来越依赖于获取来自已对未来健康结果进行随访的受试者的生物样本。这是通过使用队列和生物样本库的纵向随访以及癌症登记链接来实现的。在世界各地，越来越多基于人群的大型队列和先进的生物样本库设施得以建立。为了促进国际癌症研究以及研究结果的可比性，需要在队列、生物样本库与癌症登记处的链接方面进行国际标准化和网络化。本文提出了生物样本库、队列与癌症登记处链接的国际操作程序和标准最小数据集。为分子癌症研究提供具有国际可比性的特征明确的研究基础，将是转化医学成功的重要前提。
