Lindberg M, Emtestam L
Acta Derm Venereol. 1986;66(2):117-20.
In the present study we induced mild irritant contact reactions by using 0.5% sodium lauryl sulphate (SLS) in distilled water or with distilled water in patch tests for 6 or 24 hours. The biopsies were taken at 6, 24, 48 and 96 hours. Light and electron microscopy were used to assess the irritant reactions produced and the monoclonal antibody OKT6 was used for the detection of the LCs. The number of the epidermal OKT6 positive dendritic cells was found to be increased at 48 and 96 hours after the exposure to SLS and at 96 hours in the water patch tests. It is concluded that mild irritant stimuli cause an increase in the LCs (OKT6 positive cells) and thus might influence and modulate the response to subsequent exposures to allergens.
在本研究中，我们通过在蒸馏水或蒸馏水中使用0.5%的十二烷基硫酸钠（SLS）进行斑贴试验6或24小时，诱导轻度刺激性接触反应。在6、24、48和96小时时进行活检。使用光镜和电镜评估所产生的刺激反应，并使用单克隆抗体OKT6检测朗格汉斯细胞（LCs）。发现在接触SLS后48和96小时以及在水斑贴试验96小时时，表皮OKT6阳性树突状细胞的数量增加。得出的结论是，轻度刺激性刺激会导致朗格汉斯细胞（OKT6阳性细胞）增加，从而可能影响和调节对后续过敏原暴露的反应。
