Lindelöf B, Lindberg M
Acta Derm Venereol. 1987;67(2):128-32.
To investigate the effect of grenz rays on irritant contact reactions, eleven healthy volunteers were studied. They were given 3 Gy of grenz rays, once a week for 3 weeks, to a defined area of the back. Twenty-four hours after the last treatment, serial dilution sodium lauryl sulphate patch tests were applied both on the grenz ray treated area and on the untreated control skin. Biopsy specimens were taken from the irritant reactions both from the grenz ray treated area and from the control area and different cell populations in dermis and epidermis were identified by monoclonal antibodies (Leu 2, 3, 4, 7, Leu M1, B1, OKT6). In the grenz ray treated epidermis there was a pronounced reduction of OKT6-positive cells but the composition of the dermal cellular infiltrate did not differ between control and grenz ray treated skin. The assessment of the patch test reactions did reveal a tendency towards weaker reactions in the grenz ray pre-treated skin but this difference was not statistically significant. It is concluded that grenz rays do not have a marked effect on the elicitation of irritant reactions.
为研究格致射线对刺激性接触反应的影响，对11名健康志愿者进行了研究。他们背部的特定区域每周接受一次3戈瑞的格致射线照射，共照射3周。在最后一次治疗24小时后，在接受格致射线治疗的区域和未治疗的对照皮肤上进行系列稀释的十二烷基硫酸钠斑贴试验。从接受格致射线治疗的区域和对照区域的刺激性反应部位获取活检标本，并用单克隆抗体（Leu 2、3、4、7、Leu M1、B1、OKT6）鉴定真皮和表皮中的不同细胞群。在接受格致射线治疗的表皮中，OKT6阳性细胞明显减少，但对照皮肤和接受格致射线治疗的皮肤之间真皮细胞浸润的组成没有差异。斑贴试验反应的评估确实显示，在接受格致射线预处理的皮肤中，反应有减弱的趋势，但这种差异没有统计学意义。得出的结论是，格致射线对刺激性反应的诱发没有显著影响。
