Christensen O B, Wall L M
Department of Dermatology, University of Lund, General Hospital, Malmö, Sweden.
Acta Derm Venereol. 1987;67(4):305-9.
In the present study we produced allergic, irritant, ultraviolet and liquid nitrogen inflammation in human volunteers. Biopsies were taken from each test site and adjacent normal skin as control 4-5 weeks later. The monoclonal antibodies OKT 6 and HLA-DR were used for light microscopic detection of Langerhans' cells (LC). At all 4 post-inflammatory test sites the number of epidermal LC (OKT 6 positive as well as HLA-DR positive) were significantly increased compared to normal skin. Also, the density of dermal dendritic cells was increased in post-inflammatory test sites. The increased number of epidermal LC seems to be a result of inflammation and not a specific event strongly related to certain cutaneous inflammatory disorders. The present investigation supports the theory that epidermal LC play a role in skin homeostasis.
在本研究中，我们在人类志愿者身上诱发了过敏性、刺激性、紫外线及液氮所致的炎症。4至5周后，从每个测试部位及相邻的正常皮肤取活检组织作为对照。使用单克隆抗体OKT 6和HLA-DR对朗格汉斯细胞（LC）进行光镜检测。与正常皮肤相比，在所有4个炎症后测试部位，表皮LC（OKT 6阳性及HLA-DR阳性）的数量均显著增加。此外，炎症后测试部位真皮树突状细胞的密度也增加了。表皮LC数量的增加似乎是炎症的结果，而非与某些皮肤炎症性疾病密切相关的特定事件。本研究支持表皮LC在皮肤稳态中起作用这一理论。
