Mayeux R, Stern Y, Williams J B, Cote L, Frantz A, Dyrenfurth I
Am J Psychiatry. 1986 Jun;143(6):756-9. doi: 10.1176/ajp.143.6.756.
Among 49 consecutive patients with Parkinson's disease, 40% were depressed according to DSM-III; they had major depression or dysthymic disorder accompanied by sleep disturbance, fatigue, psychomotor retardation, loss of self-esteem, and excessive guilt. During a 10-day dopamine-free period, lumbar puncture was performed to measure the metabolites of dopamine, serotonin, and norepinephrine. Patients were given an overnight dexamethasone suppression test, and the effects of thyrotropin-releasing hormone and L-dopa on plasma growth hormone and prolactin were examined. Level of CSF 5-hydroxyindoleacetic acid was lowest in parkinsonian patients with major depression and was related to psychomotor retardation and loss of self-esteem.
在连续的49例帕金森病患者中，根据《精神疾病诊断与统计手册》第三版（DSM-III），40%的患者存在抑郁；他们患有重度抑郁症或心境恶劣障碍，伴有睡眠障碍、疲劳、精神运动迟缓、自尊丧失和过度内疚。在为期10天的无多巴胺期，进行腰椎穿刺以测量多巴胺、血清素和去甲肾上腺素的代谢产物。对患者进行过夜地塞米松抑制试验，并检测促甲状腺激素释放激素和左旋多巴对血浆生长激素和催乳素的影响。脑脊液5-羟吲哚乙酸水平在患有重度抑郁症的帕金森病患者中最低，且与精神运动迟缓和自尊丧失有关。
